In order to deal with the onslaught of npcs who are preprogrammed automata pretending to be human being, we need to be certain in identifying them. While their flesh and blood may be real, their minds fall short because an NPC can be identified very simply:
If a personoid tells you there's no such thing as qualia and that there is no "mental plane," you can be 100% certain that you are interacting with a nonhuman entity. These NPCs are less than human and should not be afforded the same rights and luxuries that human beings invented and enjoy daily.
The facts are simple: mind and body are not the same, people have experiences (qualia), and if you cannot imagine this it is safe to say that you are a deterministic automata; a machine that has been preprogrammed with a set agenda to serve human beings in some way. NPCs cannot feel, as they are less than human.
Moving on from this, what can we possibly use NPCs for? We know that there are a great many of them out there (called physicalists/materialists or some other hokey-poke name) who get very angry and defensive when it is brought to their attention that they are not alive and therefore of much lower quality than humans.
What do we do with NPCs?