Has science made any real accomplishments toward fixing our dopamine receptor deficiency yet? Give me the facts pls
It's 2022 this shit should be fixable without having to spend years locked up in a basement without internet
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What dopamine receptor deficiency, moron?
>What dopamine receptor
The dompaine receptors in my brain that don't exist but should.
so you are feeling depressed, unmotivated and lethargic? You think this is simply a dopamine thing? The fact is we don't have a damn clue about how any of this works. Dopamine theory of schizophrenia is even disputed.
> You think this is simply a dopamine thing?
Yes. I feel okay when I eat 60 mg Adderall. My brain just needs more dopamine receptors, empirically speaking. It's that simple.
>60 mg Adderall
That might just be the fix in your case.
Adderall is going to decrease your receptors moron. You can increase them but its dangerous, im not telling you how.
What do I need to do for you to tell me
>What do I need to do for you to tell me
Have sex, incel.
That's just gonna downregulate my dopamine receptors even more
adderall downregulates your dopamine receptors, literally. The brain is trying to achive homeostasis, so when you increase dopamine it reacts by shutting dopamine receptors down.
First you need to get off that bs, then work on your health.
You could ruin your life, frick up your brain permanently. More dopamine is a bad thing. Just the right amount is the key. There are stories on plebit of people who did it, not knowing what can go wrong and they basically are scarred for life and on meds for life. You should not focus on that.
Just consider the following: psychosis and schizophrenia are both associated with too mucn dopamine. You don't want that.
No that's why I'm asking here how to fix my receptors. Ppl online are crazy all they wanna do is increase their dopamine instead of fixing their receptors
I will tell you what not to do, since you claim not to be a fricking idiot: DO NOT microdose amphetamine, always take AT LEAST >5mg. Microdosing can cause tardive dyskinesia, which is a fricked up condition you don't want to have. There are reports of people who fricked themselves up with microdosing and got this condition. However they are burried deep in the reddit shit threads of people talking out of their ass about this.
Thanks bruh you have my eternal gratefulness. I promise I'm not gonna microdose that shit tho
>taking adderall
moron, just drop some acid and realize existence is futile, thus every activity can give you pleasure if you only see the good in it, there is no problem with your dope-a-memes, you just lack the guidance of divine light
not being an ass hope but bro
>why isn’t science working on this
>science created this thing that makes it better for me
go get a script for adderall. if the doc isn’t cool on that, go to another doctor
>just go to another continent bro
>Dopamine theory of schizophrenia is even disputed.
I once had a few chats with a psychiatrist, years ago, and I said to him "i think I might want to study pharmacology," and he said "really? It's mostly made up you know, we have no idea how any of this really works."
maybe he was an idiot, who knows.
Adderall doesnt give you dopamine receptors, anon.
If we can trust wikipedia,
"When amphetamine enters a neuron and interacts with VMAT2, the transporter reverses its direction of transport, thereby releasing stored monoamines inside synaptic vesicles back into the neuron's intracellular fluid.
...
in other words, the reversed membrane transporter will push dopamine, norepinephrine, and serotonin out of the neuron's intracellular fluid and into the synaptic cleft.[20] In summary, by interacting with both VMAT2 and TAAR1, amphetamine releases neurotransmitters from synaptic vesicles (the effect from VMAT2) into the intracellular fluid where they subsequently exit the neuron through the membrane-bound, reversed monoamine transporters (the effect from TAAR1).[20][21]"
So all it is doing is pushing the monoamies you have out. So why are you saying dopamine receptor deficiency rather than monoamine (e.g. dopamine) export deficiency, or monoamine deficiency (in many nutritional problems, the body slows down its "exports" e.g. constipation of hypothyroidism)?
If you had a dopamine receptor deficiency, what would the dopamine do? I guess you could argue that more dopamine means more chance that a receptor gets entangled w/ the molecule, but that is only one possibility.
Post diet, e.g. what you eat in a typical day. Do you do the IQfy self improvement trip without any success?
How does LSD make you feel? Have you taken the acid test, anon?
him being a psychiatrist saying that is very ironic. He was right, but he was still an idiot.
>him being a psychiatrist saying that is very ironic. He was right, but he was still an idiot.
I made him almost cry once by suggesting that his being a psychiatrist was like a job, and that he had a normal life outside of it and that doing his job was, like, a way to meet those other normal daily living goals.
He literally welled up with tears and said "this is...my whole life..." But he didn't cry.
You must be proud of yourself.
>You must be proud of yourself.
Yeah, I really like myself, I got the sense that he was a bit of a depressive who had poor social skills who relied on being a psychiatrist/academic to make up for his lack of self-love/normal life.
Generally I think that one of the problems with clinicians is that they are trained to avoid "human behavior" with patients, they are supposed to "play the role." In some things this makes sense, you dont want a surgeon starting to cry, but, like, he should have just showed his feelings to me, I wouldn't have minded!
You should have minded his feeling of embarrassment. Sounds like you went to a psychiatrist out of a narcissistic desire to compete with him.
>You should have minded his feeling of embarrassment. Sounds like you went to a psychiatrist out of a narcissistic desire to compete with him.
Nah, I was humoring my mother. paging dr. freud...
what's the acid test?
>Has science made any real accomplishments toward fixing our dopamine receptor deficiency yet? Give me the facts pls
We know the answer, you just don't want to hear it because it requires you to put effort into your life
The answer is "don't go on IQfy ever again, stay off of the internet/social media, limit consumerism hobbies and put effort into creation hobbies, workout regularly, sleep well, eat well". But most people will scream and cry and throw a tantrum and pretend "I can't do it, I don't have the tiiiiiiime".
I can't tell you how many people I try to help try to pretend and tell me they have no time to work on themselves.
I ask them to show me their calendar schedule, and 10/10 times they say "uh I don't have a planner or write out my day", which inevitably: how how do you have no time to work on yourself when you don't have anything penciled into your schedule in the first place?
But you don't want to hear that, you want someone to hand you something so that you don't have to put effort into life.
>"really? It's mostly made up you know, we have no idea how any of this really works."
I actually work in drug discovery, and this is very true about some things and very, very false about others.
Classic anti-depressives (guessing that's the topic here) have a mechanism that we know of, we just don't know the whole cascade or how/why it works on the macro-brain scale, because that is the "final frontier" of brain science since it's so goddamn conplex. The drug industry is a bit of a shithole and a lot of things get through the approval process that essentially doesn't work, or works terribly (lots of legacy drug-approvals would never have been allowed today). We do know a lot about reward mechanisms and a lot of what goes "wrong" with depression and other psychiatric-type disorders. Drug discovery is just still a lot of random-guesswork at the end of the day (high-throughput assays still generally do most of the hit-finding)
I heard on andrew huberman something like extra testosterone causes more dopamine receptors. Test and motivation are closely correlated.
Wash your ass, clean your room, go outside and have sex. Literally solved issue.
Meditation stupid grasshopper.
>just drop some acid and realize existence is futile, thus every activity can give you pleasure if you only see the good in it
Normalgroids truly have no souls.
>Normalgroids truly have no souls.
No, he's right.
"Maybe the dark is from your eyes, maybe the dark is from your eyes,
You know you got such dark eyes!
Nothin shakin on shakedown street. used to be the heart of town.
Dont tell me this town aint got no heart. you just gotta poke around." (Shakedown Street, Grateful Dead)
Imagine taking acid and your main insight ends up being some regurgitation of Kurzgesagt videos. Normies have no souls.
>NO NO NO, YOU CAN'T JUST BE HAPPY, YOU HAVE TO WALLOW IN SELF-PITY AND DEPRESSION ENDLESSLY
lmao, frick yourself Black person, I suffered for years and now I am free, free to do whatever I want whenever I want, nothing can hold me back, because I am human, I am alive, I have the freedom and the will to achieve anything I want to, if you want to keep pissing and shitting your diapers, go ahead, not my problem, but you shouldn't try to piss on the hand that tries to feed you, cuz you're only gonna get b***h slapped
I blame pop neuroscientists for turning dopamine in a buzzword.
Your claim makes no physiological sense. If someone has a lack of receptors, it usually means their body has become accoustomed to too high a level of the chemical.
Theodore Kaczynski
Thank you for your interesting letter, which [illegible, I received?] June 13.
You ask what qualities an individual should aspire to. First and foremost, one should aspire to self-discipline. This is a quality in which nearly all of our young people nowadays are deficient. I suspect that the deficiency is a result of excessive exposure to electronic media, “social” media in particular. In any case, I would advise you and your friends to undertake the systematic cultivation of self-discipline. For a start, I would suggest the following:
Almost all of the young people who send me handwritten letters fail to write neatly, legibly, and clearly; and you are no exception. As a first exercise in self-discipline, you and each of your friends should send me a handwritten letter that is neat, very legible and well-organized, with every word spelled correctly. Undoubtedly, you are capable of doing this; it’s just a matter of applying the necessary self-discipline.
You should undertake a program of physical training. You can start by running half a mile a day. When you feel comfortable with that, move up to a mile. And so forth, until you are running five miles at least four times a week. The object of this will not be to win races or anything of that sort, but simply (OVER) to cultivate self-discipline. And, of course, it’s always advantageous to be in good physical condition.
In view of your age I suppose you are still in school, and it may be that your schoolwork requires you to use computers. But, apart from you schoolwork, cut your use of computers iPhones, and other electronic media down to a maximum of one hour a day. This will not only be good training self-discipline — it will reduce the damage you suffer from over-exposure to electronic media.
That’s all I have time for now. Let me know how it goes.
Yours for the Revolution,
Ted Kaczynski
Yes goy, take these pills, I'll give you a great deal if you have insurance hehehe
Seriously fix yourself
Yes. Aerobic exercise is the current #1 way to reverse the neural plasticity seen in addictions (D2 receptor dysregulation).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139704/
If you seriously want to fix yourself:
>Take cold showers (they stop feeling cold after 2 minutes)
>Workout as much as possible (a good chunk being aerobic)
>Nofap