what am I in for? Got it from bgpharma just as Pax said I should. I dont have any anti fungals so I am a bit worried but this document recommends just taking NAC https://www.docdroid.net/QysFFcg/cosmicdeathfungus-pdf
just bought some deferoxamine
what am I in for? Got it from bgpharma just as Pax said I should. I dont have any anti fungals so I am a bit worried but this document recommends just taking NAC https://www.docdroid.net/QysFFcg/cosmicdeathfungus-pdf
What is this supposed to do?
its the new fingerbox
but like one of those fingerboxes that can spin out of control and suddenly a brain fungus is president of the us
You're in for making a thread about it as soon as you get it
Congratulations op! You're in for one hell of a fricking trip. Now I don't like using intranasal spray bottles and I prefer using 1ml Luer slip syringes that I can pull the needle off and stick the entire syringe up my nose till I touch the back of my nasal cavity and then push the plunger. I add 2ml of water to a vial of DFO and that gives 250mg DFO per ML. My first experience was with 125mg mixed with insulin.
I used insulin like I'd use water in this instance.
It will be quite euphoric to put it lightly.
Removing iron from the lysosome of our neurons protects them from oxygen/glucose deprivation, hyperglycemia, glutamatergic excitotoxicity, improves dopaminergic neurotransmission by decreasing the function of the dopamine transporter, and increasing the activity of tyrosine hydroxylase. It also completely mitigates the neuronal toxicity of opioids, and HIV virus and covid caused by endolysosomal deacidification.
https://pubmed.ncbi.nlm.nih.gov/17304568/
https://pubmed.ncbi.nlm.nih.gov/24146952/
https://pubmed.ncbi.nlm.nih.gov/33788818/
https://pubmed.ncbi.nlm.nih.gov/33212416/
https://pubmed.ncbi.nlm.nih.gov/23506423/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911954/
Why are you taking insulin ? Are you diabetic or is there some reason beside this ?xjnxt
Im snorting insulin for cognitive enhancement.
It's very important to understand the neuroendocrinology of insulin and its functions within the brain. The article
> "Hypothalamic inflammation in obesity and metabolic disease"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199695/
> Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders
https://pubmed.ncbi.nlm.nih.gov/35108514/
> Intranasal Insulin Improves Age-Related Cognitive Deficits and Reverses Electrophysiological Correlates of Brain Aging
https://academic.oup.com/biomedgerontology/article/71/1/30/2614162
and
> Intranasal insulin improves memory in humans: superiority of insulin aspart
https://pubmed.ncbi.nlm.nih.gov/16936707/
are critical for better understanding the pathology of cognitive decline, and cognitive enhancement.
https://pubmed.ncbi.nlm.nih.gov/35175106/
https://www.sciencedirect.com/science/article/abs/pii/S0006899314007793
https://www.jneurosci.org/content/19/22/9821
https://www.sciencedirect.com/science/article/abs/pii/S000689931730416X?dgcid=api_sd_search-api-endpoint
I'm starting to set off the spam filter I think with articles from nature and perhaps other journals. Not my intention but some of these papers I'd have to share by name.
I hope anons you're reading through these writeups, studying hard, and understand where you can find posts in the wasoru IQfy archives.
I'll post when I'm available and I'm going to plan on setting up a XMPP server and paying for advertising so everyone can reach me there. In the meantime if you have any more questions feel free I'd be willing to share whatever I can.
Thats very interesting. Im not fully done yet, but im a bit sceptical on the insulin. Its just a hunch but won't increasing basal insulin level simply accelerate the aging in the mid to long term because it will trigger a T1Diabetes or at least increase insulin resistance further ?
Wether you're wrong or not I can't tell for myself yet, but it sparked my interest for science back, and for that at least im grateful
> Its just a hunch but won't increasing basal insulin level simply accelerate the aging in the mid to long term because it will trigger a T1Diabetes or at least increase insulin resistance further
No, intranasal insulin improves markers of neuroinflammation which contributes to iron accumulation in our braincell lines. The brain relies on a population of cells in the cerebellum for promoting the uptake of insulin into the brain from the periphery. Neuroinflammation reduces the transport of insulin into the brain and its the loss of a pro neurogenic environment from insulin then that promotes cognitive decline and in particular in the hypothalamus promotes the dysfunction of a particularly important population of gabaergic interneurons which are responsible for the release of the peptide Somatostatin.
Somatostatin inhibitory interneurons are one of three populations of gabaergic interneurons within the brain that send gamma currents to pyramidal cells to control excitatory neurotransmission and exert a variety of functions in controling metabolic homeostasis and cell protection in nearly every cell line within the body. The foundations for optimal human health are grounded upon somatostatin interneurons especially within the hypothalamus. It's the loss of braincell lines within the brain that control endocrine functions and factors such as blood pressure, heart rate, even the maintenance of optimal somatostatin levels within the brain are neccesary for memory, and sensory processing. Reduced insulin transport into the brain induces a increased susceptability to glutamatergic excitotoxicity & apoptosis due to the accumulation of misfolded proteins, iron in the cytosol, free iron in mitochondria, and dysfunction of mitochondrial biogenesis and mitophagy because mitochondrial function deteriorates and that reduces anterograde transport of mitochondria to synaptic vesicles and mitochondrial integrity through reduced mitochondrial pore potential, & proton leak
There's much more behind Deferoxamine than just intranasal application for cognitive enhancement and improvements in metabolic health. Deferoxamine can be applied topically or injected into non healing wounds to promote accelerated healing and reverse skin damage and iron accumulation in the skin.
There's a wide degree of literature supporting deferoxamine use topically for the mitigation of sun exposure tissue damage or even models of chronic radiation exposure.
> Topical Deferoxamine Alleviates Skin Injury and Normalizes Atomic Force Microscopy Patterns Following Radiation in a Murine Breast Reconstruction Model
https://pubmed.ncbi.nlm.nih.gov/30113984/
> Transdermal deferoxamine prevents pressure-induced diabetic ulcers
https://www.pnas.org/doi/10.1073/pnas.1413445112
> Inhibitory effects of deferoxamine on UVB-induced AP-1 transactivation
https://pubmed.ncbi.nlm.nih.gov/10545417/
> Transdermal Deferoxamine Improves Acute Wound Healing In Chronic Irradiated Skin In A Mouse Model
the question now is what can't deferoxamine do?
You are actually schizophrenic and should seek help before you hurt yourself beyond repair.
Im the next evolution of humanity and it's not just my personal biases. The science speaks for itself
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hey man, how's it going with setting up the xmpp server, have you or them started looking into it?
>pharma shit
i'll just drink local raw malk thanks
you cringe posted
>cringe
gay talk^
gay detection confirmed. kek
Have fun anon.
Thanks anon, but why?
won't chelate iron from your brain, brainlet
>malk
looks like it already has induced severe brain damage.
>le raw shit!!
You're genuinely moronic. You know, there's a middle-ground between eating raw animal shit and GMO-infested trash?
removing the iron in the brain just makes you less susceptible to all the electromagnetic fields that make you dumb
you could have the same effect as the namegay by smoking meth in a faraday cage
i base this entirely on other schizo shit i've read
A couple of DFO threads had just been pruned so It should be important for everyone to understand that I do not pay anyone to post in my name or encourage a mass posting campaign by other anons. DFO is kind of disrupting the proper function of IQfy and there should be higher quality threads with less meme threads. I want the research to be understood and I don't want to participate in shitposting for the sake of it. everyone needs to chill and practice some self control because people are getting rightfully upset that I'm contributing to a problem of people taking all the nuance of DFO out of discussion for the sake of memes. If there should be a DFO thread then try to keep it all in one place.
>If there should be a DFO thread then try to keep it all in one place.
the 2 shill threads you made that just got deleted were both made within 10 minutes of each other you dumb shit
I didn't make those threads. There are people that have access to months worth of my personal writeups and with little effort can start shill threads and I don't have any contact with either of them or any sense of control. I haven't started any DFO threads. In fact the first DFO threads here were started because people stole from my writeups and plagiarized my work and disseminated it to practically any board they could. Those people have been stalking me and sharing my science here to shill on my behalf. The spy that started the "I have cured aging" thread even stole from my writeup and personal plea to let DFO be and to let the trend disperse. You can look in the wasoru archives where It's been said and that entire thread with multiple replies to itself even has the words in plain text that I can easily find was plagiarized word for word from the nootropics rebirth rocket chat server. https://warosu.org/sci/thread/S14547801#p14547823
"Everyone should understand that I'm fully rational when I'm stating this. Please let DFO be for now and just keep watch if you must. I don't want this to get out of hand and people get hurt because of innocent mistakes
I've gone into this to help people and I've greatly benefited from my experiment but I'm not like other people. everyone is fragile and I have to figure out the best way to move forward in the coming days"
Hey Pax, are you still planning to make that XMPP server you said about? Is it in the works? I'm very excited
My man, I wish I knew what CFS server you were on. I've read basically every study you've sent at this point so I'd love to see the more organized writeups you're working on.
We do a lot of research there in sensitive spaces controlled by a big tech company which would try to suppress us. it's highly secretive as hundreds of people with CFS are trying to attempt to heal themselves with consultation from me and other scholars.
Yeah I will make it this week, probably tomorrow or something. I barely make time to cook or eat for myself. Since I woke today it has been coffee, short walk, some music and coming online to type non stop since 8am. So it's been a lot of effort from me to take time out to juggle multiple chats, metaanalysis, and proposals for future projects such as investigating ferritin pore unfolding peptide conjugates of deferoxamine with 8x higher iron chelation capacity. This would greatly enhance the pharmacokinetics of DFO and we may be able to bind the ferritin pore unfolding peptide to perhaps any autophagy promoting compound and that would significantly promote ferritin turnover as autophagy is a process which includes maintenance of the iron proteome and proteostasis.
> Iron overload inhibits late stage autophagic flux leading to insulin resistance
https://pubmed.ncbi.nlm.nih.gov/31441223/
> IRON METABOLISM AND AUTOPHAGY: A POORLY EXPLORED RELATIONSHIP THAT HAS IMPORTANT CONSEQUENCES FOR HEALTH AND DISEASE
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361502/
> Peptides Selected for the Protein Nanocage Pores Change the Rate of Iron Recovery from the Ferritin Mineral
https://www.sciencedirect.com/science/article/pii/S0021925820430042
> A peptide selected for ferritin pore binding from a combinatorial, heptapeptide library increased the rate of Fe demineralization 3-fold (p < 0.001), similarly to a mutation that unfolded the pores. Conjugating the peptide to Desferal® (desferrioxamine B mesylate), a chelator in therapeutic use, increased the rates to 8-fold (p < 0.001)