Ever since learning about synaptic pruning in puberty I have been interested in cognitive decline, reading thousands of articles, downloading hundreds of articles, and trying to compile, chew through, and comprehend cognitive decline. However I am dissatisfied with my level of comprehension of the subjected both in breadth and depth.
Here is what I've learned thus far:
1) Seemingly nothing can stop the trajectory of broad cognitive decline. It is easier to increase intelligence than it is to maintain it, by for example aerobic exercise, but the more you do those behaviors, the more you decline after you will no longer be able to do those behaviors due to old age, because you'll lose a significant "buff" from those behaviors.
2) Nearly all domains of cognition decline, with the trend being that less g-loaded and thusly more trainable domains of cognitive ability decline more slowly, especially if trained, whereas more g-loaded and thusly less trainable domains decline more steeply. Two notable exceptions are reaction time and pair memory(i.e. "flashcards"), which have a low g-loading and high trainability, but peak very early and without trainability decline slightly below the rate of g, additionally pair memory peaks even earlier and declines more steeply than g.
3) There are two key transferable cognitive abilities that decline much less steeply than psychometric g and those are mathematical ability and especially language ability. Language ability has two key transferable factors underneath it: writing ability and reading comprehension.
4) Capacities of self-reliance, self-direction, autonomy, inductive reasoning, and making sense of the world are all domains where g saturates either a strong majority variance or is identical to the construct.
5) Knowledge increases with age but is very highly context-specific, meaning it is rarely transitive.
Do you know anything else, anons?
>Seemingly nothing can stop the trajectory of broad cognitive decline.
This homies never heard of deferoxamine
>deferoxamine
This is interesting. One of my professors at my first uni was obsessed with aluminium and IQ. Could you elaborate?
Intelligence is racist.
cope
Are there any medications, supplements or ''Nootropics''
Worth doing long term to increase intelligence or slowdown the decline?
Not nootropics per se, but make sure you don't get oral herpes and that you reduce your immune system load. It is now believed that beta amyloid MAY be involved with the immune system, making it a symptom rather than the cause. Even if that isn't the case, the link with oral herpes on rate of cognitive decline is strong and for example Phineas Gage had mushrooms growing in the hole of his brain, which lead him to have impaired cognition. When a doctor treated it with silver, then his cognition was restored. Although that's just a single case, it makes sense when you think about it. It's something broad enough to be true, but something complicated enough to be difficult to affect. On the flip side, women have a stronger immune system but steeper trajectories of cognitive decline. Another potential contender are omega 3 from nuts and seeds. The omega 3 in fish, beyond fish being high in mercury, does not pass the blood brain barrier, but its precursor ALA does, whereas that precursor can be found in nuts high in omega 3.
Any thoughts on low dosage Luvox and Cerebrolysin to repair stress induced damage to intelligence?
Is it just a cope?
Adolescent and adulthood stress do not permanently impair intelligence, only early life stress does. In old age it may even promote retention of intelligence. Stress may temporarily inhibit prefrontal cortex functioning leading to less controlled and more impulsive decision-making, but on its own it doesn't really permanently impair cognition. If you're wondering about staying at a high level performance in spite of high cortisol levels, look into Neuropeptide Y. Otherwise, I'd suggest into looking how to reduce your cortisol levels.
Cerebrolysin seems fine if you want to improve neuroplasticity/memory. It won't help your reasoning capacity or anything of the sort, though, unless you need to rewire your brain after for example a traumatic brain injury.
Stay the FRICK away from SSRIs at all cost. If you're seriously profoundly suicidal, I'd recommend therapy-assisted cognitive-behavioral therapy or psychedelics under supervision("experienced trip sitter") instead. Psychedelics increase neuroplasticity and do a lot of things like cure learned helplessness, but they also host a lot of bad effects too, like impaired visual discrimination or "flashbacks"(to be more exact, psychedelics profoundly rewire your brain, but won't make you insane. They can often imbue places you've had bad trips at with distracting, sinister overtones.) On that note, avoid THC/marijuana. It isn't necessarily toxic, but it is very highly addictive and messes with your motivation. It also in very high amounts destroys your brain, but even in low to moderate amounts isn't exactly good for you. It does, interestingly enough, improve fuzzy categorization ability, though. Furthermore, alcohol leads to messy GABA signaling, which leads to neuronal death. Neurons usually don't die, or die very very rarely. The two areas where that's an exception and neurons do die at a significant rate are the dentate gyrus and the prefrontal cortex. Neurons in the dentate gyrus regenerate, though.
What'd you do if you felt you had lost visualization capacity/creativity and felt mentally dull after suffering a concussion and covid?
I am desperate for a solution, I can't even lucid dream anymore, went from spending entire days lost in vivid imagination/ideation to feeling like I am lobotomized
Thanks for the high quality info
Dream journal, draw
No problem. I would suggest looking into psychedelics and Nogo-A inhibitors. The latter have some side-effects, but look particularly promising for nerve damage restoration, especially if combined with something like cerebrolysin. This is under-researched however, so be wary.
What about fasting?
I've heard a lot about doing intermittent fasting to reduce inflammation.
I generally do TRE of around 14-16hrs each day, just is natural for me, ezpz.
I tried keto (which turned into a fast). Big no go for me. The fats just sat in my stomach and curdled over 48 hours. Went into heavy ketosis on day 2, gave up and went to full fast for 6 days. I saw no real benefit, other than that first pizza I ate was glorious. Endless headaches otherwise.
>Stay the FRICK away from SSRIs at all cost.
This, a thousand times.
I don't know who they're for.
They messed with my head so badly, holy shit, avoid, avoid.
don't listen to that homosexual, luvox is superior, it synergises with brexpiprazole and atomoxetine to increase monoamine and acetycholine in the PFC
>antiparkinson effects of fluvoxamine
https://pubmed.ncbi.nlm.nih.gov/32273939/
https://pubmed.ncbi.nlm.nih.gov/27338206/
>anti Alzheimer's effects of fluvoxamine
https://www.neurologylive.com/view/sigma1-agonists-offer-combination-approach-to-dementia-symptoms
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819237/
>general cognition enhancing effects of fluvoxamine
https://pubmed.ncbi.nlm.nih.gov/20373470/
>sigma-1 agonists raise acetylcholine in the frontal lobes and hippocampus but not the striatum and reverse memory impairment from muscarinic blockade
https://pubmed.ncbi.nlm.nih.gov/20060423/
>fluvoxamine dopamine in the frontal lobes
https://pubmed.ncbi.nlm.nih.gov/21487652/
>prazosin (a1 adrenergic antagonist) prevents memory deterioration in Alzheimer's
https://pubmed.ncbi.nlm.nih.gov/23063647/
>a1 blocker reduces risk of parkinson's
https://medicine.uiowa.edu/content/prostate-drug-associated-lower-risk-parkinsons-disease
>5ht1a agonism increases dopamine and acetylcholine in the PFC
https://www.sciencedirect.com/science/article/abs/pii/S0166432808002933?via%3Dihub
>5ht1a agonism raises striatal dopamine
https://pubmed.ncbi.nlm.nih.gov/15906386/
>cognitive benefits of a2c adrenergic antagonism
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558054/
>procognitive effects of atomoxetine
https://pubmed.ncbi.nlm.nih.gov/16231039/
> monoamine
Did you mean monoamineS
> luvox
Fluvoxamine is an SSRI. You can mess with dopamine and all other stuff as much as you want, but do NOT mess with serotonin. (https://en.wikipedia.org/wiki/Serotonin_syndrome)
>sigma-1 agonists raise acetylcholine in the frontal lobes and hippocampus but not the striatum and reverse memory impairment from muscarinic blockade
Okay anon, and are you regularly ingesting deliriants? lol Sigma-1 is a DMT receptor, by the way.
Oh and by the way:
> Atomoxetine inhibits the presynaptic norepinephrine transporter (NET), preventing the reuptake of norepinephrine throughout the brain along with inhibiting the reuptake of dopamine in specific brain regions such as the prefrontal cortex, where dopamine transporter (DAT) expression is minimal.
> Extracellular MDMA binds to presynaptic serotonin (SERT), norepinephrine (NET) and dopamine transporters (DAT) as a reuptake inhibitor, so that they uptake less of their namesake monoamine neurotransmitters. The efficacy of MDMA inhibition is highest towards NET and SERT, and is much less towards DAT.
> Methamphetamine has been identified as a potent full agonist of trace amine-associated receptor 1 (TAAR1), a G protein-coupled receptor (GPCR) that regulates brain catecholamine systems.[108][109] Activation of TAAR1 increases cyclic adenosine monophosphate (cAMP) production and either completely inhibits or reverses the transport direction of the dopamine transporter (DAT), norepinephrine transporter (NET), and serotonin transporter (SERT).
>hurr durr maximize all neurotransmission
No moron. You want to be hungry when you have a caloric deficiency and satiated when you have a caloric surplus. If you take this drugs, you introduce noise into your neurotransmission, feeling hungry or satiated when you shouldn't be, and throw the whole brain out of whack. That's NOT how it works.
So if you're comfortable with crystal meth, taking ecstasy on the daily, regularly ingest deliriants
then go along, but don't push your degenerate junkie bullshit as having anything to do with "health" and "retaining cognition"
what a stupid and biased fricking post
go read some more of your bible moron
> I don't know know what deliriants, monoamines,
and reuptake mechanisms are.
> God loves people taking DMT
> Strawmanning to the max
I'm from the most atheistic country in the world, sweaty. That doesn't mean I should be degenerate like the likes of you. Furthermore, this is about preventing cognitive decline not improving cognitive performance. All of the shit that was written there is just hardcore drugs made legal that over time fry your brain. But if you just want to be smart NOW or need to perform NOW, then go right ahead. But realize like Erdos you're just doing meth, you're not doing some new clean wonderdrug, you're literally doing meth. Please consider whether you care for the thing enough or whether you have the balls and capacity to avoid addiction for doing meth.
I remember trying Atomoxetine, and it being the first time in my life where I felt actually in control of my daily routines and didn't struggle to sit down and get things done
I had to discutinue it cause it'd start to make me feel depersonalized/insomnia later on
How your parents CUM during sex determines your intelligence.
IF your dad makes your mom orgasm repeatadly and then blows his blows his load like a fire hose then you'll be born a chad with 140+ IQ.
ITS ALL ABOUT HOW YOUR PARENTS CUM.
intranasal deferoxamine
intranasal insulin
intranasal Epobis
>designers
>social workers
>administrators
>public relations
>commissioned officers
lol no
lol yes.
I am more intimately aware of the chart you sent and all its details, nooks, and crannies. It's from Emil Kierkegaard's where he stole it from a Canadian study published in a pop-science journal using ENTRY-LEVEL GRE in mathematics and verbal ability. What you think you know is irrelevant. Writing ability correlates more strongly to intelligence than mathematical ability, because except for pure mathematics and mathematicians, no one actually reasons with mathematics, everyone just uses it like a little programmed drone.
In any case with that debunked, I'd further point your attention to when the study was conducted. We're talking about late 20th century designers here, not web designers. That's a stark difference. The prior are involved with things like making sure the speakers in a rock concert don't either cause permanent hear damage, nor are too quiet to hear at the back of the crowd. The latter are involved with making a site look pretty. Social workers, administrators, and commissioned officers must have a tight comprehension and aptitude for logistics. Furthermore with public relations and commissioned officers there is a rigorous selection process, especially for the latter, so it's not that much the occupation in and of itself requires a lot of brain power, rather that people with brain power are selected for the job in virtue of a selective process. They must, however, also engage in a high amount of high quality writing ability. You wouldn't want to start a war with another country just because of an ambiguously stylized sentence, would you now, anon?
In any case, nearly all of those occupations, except for the officers which are literally selected for IQ if you've ever been to the army, are at the bottom of that chart and this is strong empirical data with a sample size of 10k people.(Wisconsin Longitudal Study) So I'm not going to take a one syllable word and a lowercase acronym of an inerudite Internet stranger above data.
*that's not to say you can't use mathematics to reason. Most certainly you can! Most people just don't, because they're not initiated into it.
If mathematical and language ability don’t trend downwards like the rest who cares?
Mathematical skill is intelligence. End of fricking story. All other ”””””””””intelligences””””””””” is just nonsense.
If mathematical skill stays the same then nothing of value was lost, abstract problem solving is the only worthwhile skill you need in your brain
how come no one has mentioned psylocibine yet
>“We not only saw a 10% increase in the number of neuronal connections, but also they were on average about 10% larger, so the connections were stronger as well,” said Yale’s Alex Kwan, associate professor of psychiatry and of neuroscience and senior author of the paper.
I know that your neurons need fat (good fat ofc) to work at their 100%
Doing certain things will activate certain zones of the brain
Being, scared, angry or happy will activate the brain too
When you grow older you don't have to study for hours so you can work in those extra bumps