I'm permanently high from increased potentiation and phosporylation of my neuronal insulin receptors on all of my neuronal cell lines I'm restoring neuronal insulin sensitivity by chelating iron. Deferoxamine doesn't work like normal drugs because it chelates iron. All the mechanistic effects of deferoxamine is based on removing iron that has accumulated within the cytosol of your neurons and other cell types.
Removing iron that's accumulated by the dissociation of iron from mitochondria through endolysosomal deacidification from opioids or viruses, or from the accumulation of hepcidin or glutamatergic disinhibition reduces the healthy function of all cell types within the brain and its the main causal factor behind the degeneration of our metabolic homeostasis and our neurological functions
This is controlling neuronal insulin resistance allowing insulin to better support the neurotrophic supply and glucose metabolism, and steroidogenesis for pregnenolone that promotes the outgrowth of microtubles on our neurons and hypothalamic inflammation that promotes neurological disorders and metabolic disease share this common contributing factor
Neuronal insulin resistance from the accumulation of iron is the main pathological factor in the loss of proteostasis and the use of iron in protein synthesis. Excess free iron that is lost to the cytosol from endoplastic reticulum stress from LPS and saturated fat induced lipotoxicity promotes the dysfunction of mitochondria within our brain cells and promotes the functional decline of these cell types and it induces the cellular senescence and transcriptional drift in these cell lines through the dysfunction of our livers and blood brain barriers that promotes bacteria, virus, and fatty acid, ammonia and bilirubin accumulation within our brain and the reduction of cholesterol metabolism and this promotes sphingolipid accumulation in the lipid rafts of our brain cells contributing to the reduction in cell viability.
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Iron accumulation within our braincells occurs and that promotes neuronal insulin resistance. Insulin resistance leads to the breakdown and reduced insulin transport to the brain which is the root cause of all neurological and metabolic disorders.
I've removed all the iron from my brain that contributes to neuroinflammation and reduced synaptic plasticity. The data I've shared to support those observations, the observations why i'm high and the data to support why my fatigue is significantly reduced, my attention and learning is much better, my reference memory is perfect and all of that data is supported by the body of literature I've posted.
If you had just read the metaanalysis of the mechanisms of intranasal deferoxamine which I've shared on IQfy everyday when asked questions for the past 2 weeks you'd understand it.
None of you have read all of the literature I've shared in the past weeks and the data supports my arguments.
The title to many of these papers supports the scientific observation by the collection of data to support my metaanalysis of nootropics enthusiasts don't read before they ask questions. Read the papers, the literature speaks for itself!
I could fricking die and none of you would be able to ask questions then. You have to LEARN!
I'm here to teach, You're here to learn and to disseminate this information as you please and apply it for the treatment of metabolic and neurological disorders and heal every person you have ever known of every disease you can imagine because I have this brain that just holds all of the medical literature in my fricking head
If I ever go to university I'm making my PHD thesis my observations of the failure of following a line of logic when it comes to the approach of cognitive enhancement and the inherent deficit in application of new data and tools available to promote cognition and the implied improvement in cognitive function that some people have reduced ability to promote cognition with nootropics because they understand less literature and apply simpler directed targeted small molecule drugs over that of targeting pathways like insulin sensitivity.
I'm going to put you and everyone in that paper if you don't read before asking questions because I posted the data days ago saying literally intranasal deferoxamine improves memory in healthy mice
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066355/
Intranasal deferoxamine may promote a fungal infection in your brain that can KILL YOU.
The only latent symptoms are headache, double vision, before partial paralysis and death.
Intranasal rapamycin has a strong ability to mitigate and prevent this from happening and I snorted 50+mg earlier tonight and will continue to use rapamycin intranasally instead of insulin for a couple days because I've got the suspicion that I may have this condition
I've paid thousands of dollars for nootropics and other projects and put countless hours and spent hundreds of dollars a month on fast food each month just so that i could develop the foresight to bring deferoxamine to the attention of everyone.
China sells it for the equivalent of $90 per 5 grams. That will not be the price you pay for me to make any money, for the people involved in helping me. Our logistics and personal networking and connections with laboratories has come from the collective effort of our entire community to get this far. I will not go broke so that you will have a bigger more well connected brain.
if what I think is possible and we can apply DFO to peptides to improve its efficacy we can create a compound X8 as effective by weight as deferoxamine
Deferoxamine is a drug that literally pulls iron from your brain that's accumulated in your brain cells and reverses cerebral insulin resistance mitigating not only the progression of cognitive decline and intellectual deficit but also metabolic disorder
This drug used by this MOA will be so incredibly powerful that when I decide to give a dissertation of iron and its relation to metabolic and cognitive disorders the reverberations that my words will come out to shake the world to its foundation
I'm spending over $10k of my personal wealth researching and funding development of powerful new drugs that havent been used before
i'm the first person to use 500mg of intranasal deferoxamine. I've not made a single dollar in over a year from this project.
I'm just someone that's been self taught and driven to understand the pathology of neurological and metabolic disorders after I joined a niche advanced nootropics group for the understanding of cognitive enhancement and I had 7 years of self study before I joined the group. There is a couple neuroscientists that I've been close friends with for a year. One I've had a huge rivalry because they kept asserting that factors that improve metabolic health can't improve G and I took that personally. So I've begun snorting insulin intranasally and that's after I've pioneered the use of rapamycin intranasally, and the introduction of SKQ1 as I was the first person to give a dose report. There's a DFO thread that someone has made the other day that I'm replying to and giving insight. I'm just this heavily autistic person that obsessed over health and longevity based on being surrounded for years by disease and abuse and I needed an intervention to allow me to adapt to my environment. I've gone through about 4 of the vials I've had intranasally. Here's a paper demonstrating the use of DFO as a prophylactic for stroke and it'd reduced ischemic stroke induced cell death by 55%
https://jpet.aspetjournals.org/content/330/3/679.short
And here's a larger metaanalysis of the mechanisms of intranasal deferoxamine.
I use about 125mg-250mg pd and I've went through about 2.5 grams.
I believe I may have developed fungal sphenoid sinusitus that could be deadly and the only sides before partial paralysis is headache and visual disturbance. I had some astigmatism earlier tonight so I've had some powdered rapamycin in my desk which I snorted 50+mg from my vial which should be a powerful antifungal. Don't worry I think I might be fine but definitely be aware of that
forgot to post the second study but here it is.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911954/
Here's another paper supporting DFO administration for mitigating the progression of the APP model of alzheimers disease
https://www.frontiersin.org/articles/10.3389/fnagi.2015.00104/full
and here's one in healthy mice.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066355/
This is only a small ammount of the data from the medical literature to support my neuronal insulin resistance model of metabolic and neurological disorders which are all supported by the hypothalamic inflammation model of metabolic disorder and a decline in insulin evoked cell functions within our brain cells which occur due to iron accumulation aggravated by LPS and other inflammatory factors such as high opioidergic tone in obesity, cortisol from chronic mild stress, hyperammonemia within the brain, bilirubin breakdown by heme oxygenase which promotes iron accumulation in microglial cells
https://www.sciencedirect.com/science/article/pii/S2213231720309940
I have a vial of 2 grams of rapamycin that i'm snorting from. This promotes significantly lower systemic concentrations of rapamycin than injection or oral use but 25 fold higher levels than subq injection. I've snorted about 100mg tonight. https://pubmed.ncbi.nlm.nih.gov/30876754/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218962/
https://www.mdpi.com/2072-6651/4/9/718
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294450/
rapamycin is nontoxic to brain cells and I've snorted more than any human alive.
https://pubmed.ncbi.nlm.nih.gov/30175977/
When everyone on 4 chan thinks that I'm insane without question and they cant even understand the science I share that should give you serious pause
NOONE FRICKING USE DFO IF YOU'RE NOT EXPERIENCED OR PREPARED FOR POTENTIAL OBLIVION
I'm uncommon amongst uncommon people
I'm the person that introduced intranasal deferoxamine to the world and now i have to control it
To the Fake Pax if you're watching this I'd like you to stop sharing from my writeups for now and dont have anons replicate my experience if they're novices
Deferoxamine is the most powerful drug ever created
Everyone should understand that I'm fully rational when I'm stating this. Please let DFO be for now and just keep watch if you must. I don't want this to get out of hand and people get hurt because of innocent mistakes
I've gone into this to help people and I've greatly benefited from my experiment but I'm not like other people. everyone is fragile and I have to figure out the best way to move forward in the coming days
you are late
I'm getting lost
in your first post you say
>Removing iron ... reduces the healthy function of all cell types within the brain
but in your second post you say
>I've removed all the iron from my brain that contributes to...
do you want to keep the iron/insulin resistance or do you not?
also, if you're trying to free the iron from the cells, would it be useful to rub magnets all over your head? serious question
tell your troony discord buddies i wish them a happy 41%
Where do these kinds of screenshots come from, I wonder? Who would post that shit in the open?
That board style is leftypol
Bunkerchan. They're as schizophrenic about /misc/ as /misc/ is about israelites.
What kind of iron lodges in the brain and why does it stay there?
Do I have to take Deferoxamine every single day of my life to ascent or is it a lasting effect which stays with me after stopping to take it?
I'm not reading all that shit
Why novartis? Shows the drug is already off patent.
Enjoy your comedown i guess
You're wrong.
Proof: I said so
Never leave you austistic bastard
You are actually schizophrenic and should seek help before you hurt uourself beyond repair.
Nice writing OP, such densely packed information in a prose reads as if one can hear you speaking
any holistic methods that may reduce this free iron created when the body is trying to clean up the junk food?
>holistic methods
Consuming a plant based diet promotes lower body iron accumulation than heme iron while having similar hemocrit levels.
Consumption of phytonutrient rich plant foods such as cruciferous vegetables and high amounts of fiber from foods like beans increase butyrate production in the gastrointestinal tract that preserves the gastrointestinal barrier. Consuming meals rich in carbohydrates increases tryptophan uptake into the brain which is metabolized into serotonin and then that serotonin activates cells within the cerebellum that increase insulin transport into the brain. This supports why a diet low in bcaa's increase metabolic health is because bcaa's compete with tryptophan for metabolism and this increases cortisol release and cms.
The loss of insulin sensitivity also reduces bcaa catabolism in the body which promotes tumor growth and acceleration of aging
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853195/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424797/
https://pubmed.ncbi.nlm.nih.gov/28323986/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506390/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814438/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728689/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813603/
Directly increasing neuronal insulin sensitivity increases metabolic homeostasis and bcaa catabolism. The failure of bcaa catabolism aggravates organ fibrosis, cancer growth, etc
https://www.sciencedirect.com/science/article/pii/S2211124716307331
why can't you answer this post
you fricking moron
sage
Yes.
great job answering the second question, now answer the first question
now way mangets are scary
clearly underage
tons of run-ons and still hasn't even answered his question about whether removing the iron or trying to preserve it
>sage
no
You are the moron learn to fricking read.
>neuron metabolism produces iron
>iron isn't evacuated and accumulates
>increasing level of iron means more energy used to keep the neuron healthy instead of promoting other pathways
>the neuron can't be insulin stimulated enough to intake all the glucose it needs to keep running
To prevent this Op uses DFO which chelates iron and makes it eniminable. Lower iron level in the neuron means less insuline resistance and more energy going into other celullar activity. Since neuron are largely irreplaceable, it extends their longevity and reduces aging.
maybe you are the one that needs to "learn to fricking read"
in my original post I point out that I read it all but that there were contradictions
if he is trying to lower the iron level in the neuron, then why does he say the following
>Removing iron that's accumulated by the dissociation of iron from mitochondria through endolysosomal deacidification from opioids or viruses, or from the accumulation of hepcidin or glutamatergic disinhibition reduces the healthy function of all cell types within the brain and its the main causal factor behind the degeneration of our metabolic homeostasis and our neurological functions
to paraphrase, I'm reading that as "Removing iron that's accumulated ... reduces the healthy function of all cell types within the brain"
as the other anon said, OP doesn't use appropriate punctuation so I don't know if that is the correct interpretation
one other possibility is that I'm reading this correctly, but not understanding something
I don't understand why you would want to remove iron if that would reduce a healthy function
https://en.wikipedia.org/wiki/Neurodegeneration_with_brain_iron_accumulation
Here you go. Its not even niche or complex. Its more than likely a typo and he corrects himself later on.
You are reading correctly and OP likely made a mistake, but it is disambiguated later on.
Happening!
Okay
How do you prevent the shortening of the telomeres then ?
with pilates
Just use the immortal jellyfish combined with the memory transfer ability of a larvae to cocoon and butterfly, and stop cheating yourself in an emotional whirl.
I know it sounds stupid, and very fricking simple, but it does work.
All perfectly mapped for you, all biological functions in constant move and shape.
Much like the microscopic imagery of a burrowing tape worm yielded the shape of the mass burrowing drills for deep earth excavation, or bird wings gave us planes.
It's all in plain sight, you just have to extract it all.
Besides, you will find it is actually more complicated than first meets the eye, but the chemistry behind it is pretty easily replicable, especially with an AI system to play the metaphorical DNA piano keys to figure out what string does what.
Then all you have to do is ask it to draw parallels between jelly+butterfly specific DNA admixturr and humans, tell the AI to draw you a parallel mechanism, scale it to human size, reproduce it, and sleep a near eternal sleep...
Until some morons come knocking on your door because they somehow ruined it all.
"Design an idiot proof system, and the universe will design a better idiot."
Hyperbaric oxygen therapy
I HAVE REACHED SUPERHUMAN LEVELS. Just snorted 1gram of Deferoxamine today, and feel like I’ve never felt before in my life.
I HAVE OFFICIALLY CURED EVERY DISEASE IN THIS EARTH.
Iron accumulation was never supposed to happen, and that is what is causing all of this. Autism, Schizophrenia, alzheimer, you name it.
I AM NOW BEYOND GOD LEVELS, and I will make you all cured, and live the best lives you can.
Based
homie is going to die...
>mfer snorts od quantities of mistery shit from aliexpress just to post BAne? threads on IQfy
I want to see how far he goes
Morb..
>I want to see how far he goes
no brakes on this train, we're bound for eternity
>anon gets an heart attack from the speed-laced "medicine" and dies
>doctor says it was SADS
lol, lmao even
sounds like you're on basic meth to me
This is the best DRUG EVER. EVERYONE BACKUP THE INFORMATION HERE IMMEDIATELY.
Cleaning the Iron from the brain will reverse ageing, will make you reborn. I’ve never felt like this in the past 30 years. Absolutely incredible. I AM THE NEW GOD. New order.
Why are vegans always so mentally ill?
Not a bad thing
Yes it is. They're always scouring the literature for evidence that veganism is THE ONE TRUE DIET. Ironically, they couldn't be more wrong.
how's your working memory?
can you do mental arithmetic and multiply large numbers in your head?
Publish it on arxiv, and then on a reputable journal. Without clinical experiments required, this is all conjecture and there is no reason people should trust a weeb.
I'm trying to follow, you're talking about removing accumulated iron... how is that not fricking around with your blood cell count? If that's true, your red blood cells will diminish and your entire body will enter anemia and be attacked by white blood cells and you'll go into leukemia or something...
picture wtih timestamp of lab equipment NOW
Schizo OP is snorting some substance he got from China called deferoxamine and rapamycin and is reporting significant cognitive enhancements. Supposedly this is done by removing excess levels of iron from your brain or some shit
Taking deferoxamine to reduce iron concentration in neuron and prevent aging. Reducing iron supposedly lowers insuline resistance, so your brain doesn't consume more and more sugar to perform at base level which reduces neuron damage.
Op also takes rapamycin to activate the mTOR pathway, which triggers cellular reparation mechanism, to further prevent aging.
They are taken nasally, which is more important for deferoxamine since it is the only administration method that led to significant cognitive alteration in rats
Dosages are unreliable as OP seems to be winging it. OP is also snorting antibiotics to thwart a possible fungal infection, which isn't completely unhinged since rapamycin is an imunosuppressant used in transplantation patients to prevent rejects.
The use of chelating agent can lead to severe side effects and there have been deaths in the past because of them
The use of rapamycin in non transplantational context is controversial and dangerous to an extent, although it has been done. It still exposes you to higher chances of cancer and infectious disease
A few correction on rapamycin.
It doesn't cause cancer contrary to many other immunosupressant, but it has an array of side effects such as oedema.
Rapamycin doesn't promote mTOR, it inhibit it.
Through mTORC2 inhibition,rapamycin causes insulin insensitivity, which can cause diabetes like symptom. So the whole preventing insulin resistance could be compromise, depending of course on the balance of effects. Removing iron acts on multiple factors so maybe lower insulin tolerance isn't what is causing these mices to have better cognitive ability.
OP bought magnetic meth from alibaba and snorted it. claims it will pull the iron out of his brain, which is good according to him.